We used the Orion fluoride electrode systemtodeterminethe
normal range of serum ionic fluoride concentrationsand to investigate its
relationship to sex and age (A). 87normal men, age 18-92 years (mean, 46
years), and 49normal women, age 19-64 years (mean, 38 years), participatedin
the study. At the 95% confidence limits, males<45 years old had a normal
range of 0.29 to 1.52 moI/litre and males
45 years old 0.29 + 0.0101 (A-45)to 1.52+ 0.0101 (A-45) tmol/litre.
Females, however, had anormal range of 0.022A - 0.32 to 0.022A + 1.07 tmol/litre.
A group of 51 men 18-44 years old was comparedwith a group of 36 men 46-92
years old. The mean serumF of the older group was shown to be significantly
greater(P <0.01)than that of the younger group. Factors relatedto serum
ionic fluoride values are (a) tea as an importantsource of dietary F, (b) the
lack of significant variationduring daytime hours, and (C) the lack of
significant differencein concentration between serum and plasma F.Concentrations
of serum constituents in normalpeople are in some cases affected by sex and age
(1).Recently, in determining the normal range of serumionic fluoride in groups
of males and females of differentages, we also noted that age and sex exerted
some influence.Although chemical methods (2-5) for measuringserum fluoride have
been known for over 25years, it is only since 1968 that it has been recognizedthat
fluoride in human serum is partly ionized (6, 7)-chiefly because an instrument
for convenientlymeasuring ionic fluoride (8-9) became commerciallyavailable in
1966. The importance of serum ionic fluoridemeasurements is further emphasized
in view of theclinical use of fluoride as a treatment for osteoporosis,either
alone (10, 11) or in combination with other substancessuch as calcium and
vitamin D (12)
Open Source:
.http://www.clinchem.org/content/22/11/1884.full.pdf
Open Source:
.http://www.clinchem.org/content/22/11/1884.full.pdf
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